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Azilsartan 147403-03-0 Azilsartan 147403-03-0

Azilsartan 147403-03-0
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Maklumat asas Azilsartan

Name

Azilsartan  

Alias

2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid; 
Tak 536; Unii-F9nux55p23;
2-ethoxy-3-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid; 
Azilsartan 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid; 
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid; 
Azilsartan (TAK-536)

CAS NO.

147403-03-0

Molecular Formula

C25H20N4O5

Molecular Weight

456.45

Quality Standard

JP/ GMP / 99%min

Grade Standard

Medicine grade

Package Size

25kg/drum

Penggunaan Azilsartan

Azilsartan adalah perencat reseptor angiotensin II yang menurunkan tekanan darah dengan menyekat aktiviti reseptor angiotensin II, berbanding dengan pengangkatan antihipertensi enzim penukar enzim (ACEI) angiotensin. Ia mempunyai kelebihan tekanan darah halus, tidak menyebabkan batuk kering.

COA Azilsartan

Analysis Items

Specification Limit

Result

Appearance

White to almost white powder

Almost white powder

Identification

Meet reference standard

Conform

Loss on drying

NMT 0.5%

0.1% below

Specified impurity (RRT2.1)

NMT 0.1%

0.01% below

Specified impurities(RRT2.4)

NMT0.1%

0.01%

Any other individual impurity

NMT 0.1.%

0.04%

Total impurity

NMT 0.5%

0.08%

Ethanol

NMT 5000ppm

37ppm

Acetone

NMT 5000ppm

10ppm below

Assay

NLT 99% calculated on the dried basis

99.6%


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MORE_DETAIL Azilsartan 147403-03-0

Maklumat asas Azilsartan

Name

Azilsartan  

Alias

2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid; 
Tak 536; Unii-F9nux55p23;
2-ethoxy-3-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid; 
Azilsartan 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid; 
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid; 
Azilsartan (TAK-536)

CAS NO.

147403-03-0

Molecular Formula

C25H20N4O5

Molecular Weight

456.45

Quality Standard

JP/ GMP / 99%min

Grade Standard

Medicine grade

Package Size

25kg/drum

Penggunaan Azilsartan

Azilsartan adalah perencat reseptor angiotensin II yang menurunkan tekanan darah dengan menyekat aktiviti reseptor angiotensin II, berbanding dengan pengangkatan antihipertensi enzim penukar enzim (ACEI) angiotensin. Ia mempunyai kelebihan tekanan darah halus, tidak menyebabkan batuk kering.

COA Azilsartan

Analysis Items

Specification Limit

Result

Appearance

White to almost white powder

Almost white powder

Identification

Meet reference standard

Conform

Loss on drying

NMT 0.5%

0.1% below

Specified impurity (RRT2.1)

NMT 0.1%

0.01% below

Specified impurities(RRT2.4)

NMT0.1%

0.01%

Any other individual impurity

NMT 0.1.%

0.04%

Total impurity

NMT 0.5%

0.08%

Ethanol

NMT 5000ppm

37ppm

Acetone

NMT 5000ppm

10ppm below

Assay

NLT 99% calculated on the dried basis

99.6%

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